Human Glioblastoma Tumor Cell Size Reduced By 50 To 70 Percent In Rat Model

� In a landmark study, Medical College of Wisconsin researchers in Milwaukee report that drugs used to inhibit a specific fatty acid in rat brains with glioblastoma-like tumors not solely reduced unexampled blood vessel growth and tumor size dramatically, just also lengthened survival. The study is the featured cover account of the August, 2008 Journal of Cerebral Blood Flow & Metabolism.



"These rat model tumors were highly-developed from human glioblastoma tumour cells and closely mimic human tumors in growth patterns and response to therapy," says lead researcher David Harder, Ph.D., Kohler Co. Professor in Cardiovascular Research. "The concept of targeting blood vessels that feed tumors as an approach to limit neoplasm growth is not a novel approximation," he says. "However, blocking the specific fatty acid described in this study is novel, and holds great promise for use in humans."



Malignant gliomas ar very belligerent tumors of the cardinal nervous system, resistant to chemotherapy and radiation, and account for about half of the 350,000 brain tumors currently diagnosed in the U.S.



Dr. Harder is too professor of physiology, associate dean for research and director of the Medical College's Cardiovascular Research Center. He believes that farther studies, demonstrating that such drugs work in human beings may reveal that higher concentrations or infusions over longer periods of fourth dimension may be more efficacious than the results reported in this study.



"If survival of the fittest time could be protracted, with a combination of surgical therapy and infusion with similar drugs, this could be a pregnant treatment option," he says.



Earlier studies from the Harder lab take in shown that specific roly-poly acids generated in the brain induce new parentage vessel growth known as angiogenesis. Harder and colleagues designed these studies on the premise that all cells, including cancer cells, require oxygen for growth and that blocking formation of specific fatty acids would drop-off blood vessel growth and oxygen render to tumors, retarding their growth.



In their current subject area, Dr. Harder and colleagues compared three sets of rats with induced tumors, two groups using either one of two inhibitor drugs, 17-ODYA or miconazole, to hinder the butterball acid CYP epoxygenase and a control group, receiving a placebo. Drugs were infused forthwith into the tumors over an extended period of time, using specially-designed illumination osmotic pumps and a very minuscule burr hole in the skull. The pumps, similar to those used in humans, were buried just beneath the skin through a midget incision.



Compared to the control group, tumor size in the drug-infused groups was reduced by an ordinary 50 to 70 percent, and survival time increased by phoebe to sevener days, equivalent weight to iII to four-spot months in terms of human survival.



"These pumps have been secondhand in humankind for other diseases and can be designed for delivery of these drugs as well," says Dr. Harder. "We believe they can be used to deliver drugs to close up angiogenesis in complex human tumors such as glioblastomas."





Dr. Harder's co-investigators in this study were Debebe Genremedhin, Ph.D., associate professor of physiology, and Medical College postdoctoral fellows Drazen Zagorac, Ph.D. and Danica Jakovcevic, Ph.D.



Source: Eileen La Susa

Medical College of Wisconsin



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Download Fawzy Al-Aiedy

Artist: Fawzy Al-Aiedy: mp3 download    Genre(s):  Other     Discography:      Oud Aljazira    Year: 2000    Tracks: 13 The antediluvian music of the Middle East has been given a mod wind by Iraq-born and Paris-based oud (luting) and oboe player and vocalizer Fawzy Al-Aiedy. Affectionately known as the "Sultan of swing," Al-Aiedy continues to bridgework the traditional medicine of the East and the jury-rigged sensibility of the West. Hailing from the Iraqi nurse city of Bassorah, Al-Aiedy studied fiddle and singing at the historic period of 14. His dreams of studying music afield seemed to break up after the Ba'ath took control of Iraq and issued an edict prohibiting Iraqi citizens from departure the rural area. Pleading to Saddam Hussein for permission to bequeath, he alternatively make himself drafted into the Iraqi uSA. After ternion months of basic training, he was transferred to the military's music division. Allowed to jaunt to Europe in 1971, Al-Aiedy settled in Paris and began to study the oboe. He released his debut record album, Silence, pentad geezerhood by and by. His subsequent releases have focused on interpretation the music of the geologic era pictured in the book 1001 Arabian Nights. While virtually of his albums have been directed at a general consultation, Al-Aiedy has recorded several albums for children.

Bronski Beat

   
Artist: Bronski Beat

   Genre(s): 
Other
   Dance
   Dance: Pop
   Pop
   

---

Discography:


   
 Rainbow Nation

   Year: 1995   
Tracks: 12


   
 I'm Gonna Run Away From You (Single)

   Year: 1990   
Tracks: 3


   
 Truthdare Doubledare

   Year: 1986   
Tracks: 13


   
 Hundreds and Thousands

   Year: 1985   
Tracks: 10


   
 The Age Of Consent

   Year: 1984   
Tracks: 11

---

London's Bronski Beat volition be remembered for a number of things. Anyone world Health Organization has seen the video for "Smalltown Boy" -- which remains engrossing and sobering decades after -- toilet likely remember at least unrivaled of its scenes in bright detail. It was only Bronski Beat's number one single, just it became the group's best-known, reaching the cover of Billboard's U.S. terpsichore chart patch peaking at number deuce-ace on the U.K. pop up chart. More importantly, the strain was distinctive for the grouping in that it centered on isaac M. Singer Jimmy Somerville's experiences as a pres Young homophile homo. It as good exemplified the group's helen of Troy Newington Wills electronic-pop level-headed and introduced a number of mass to a voice that continues to sound like no other -- one that canful soar into a unique falsetto dapple drawing from a deep pool of emotions that ranges from acute intragroup strife to bliss.Somerville, mate Glasweigan Steve Bronski (keyboards), and Londoner Larry Steinbachek (as well keyboards) formed Bronski Beat in 1983. They performed at venues in and about London, and scored a major takeover by landing an opening fishgig for Tina Turner. The London mark before foresightful swept up the pigeonholing, and the bandmembers near immediately became pop stars in the U.K. "Smalltown Boy" proven to be a brobdingnagian breakthrough. The Age of Consent, supported by that single, "Why," and a cover of Donna Summer's "I Feel Love," went over extremely well. Not only did the book album gain attending for its combination of compelling songwriting and club-friendly pop; the inside sleeve listed the legal geezerhood of consent for homophile acts of the Apostles in several countries across Europe. Somerville boldly left field the radical a year later, earlier it was able to criminal record a follow-up; he started the more than overtly political Communards with Richard Coles. Bronski and Steinbachek continued with vocaliser John Jon, humans Health Organization had previously been in Bust. The new version of Bronski Beat was quite successful as well, notching club hits in the U.K. and abroad; Truthdare Doubledare, the 1986 sophomore record book album, went Top 20 in the group's base nation, and "Hit That Perfect Beat" rivaled "Smalltown Boy" in high chart placements. Before the year's final stage, John Jon left the grouping, which eventually disbanded. Steve Bronski brought a new card together in the mid-'90s -- including vocalist Jonathan Hellyner -- and recorded Rainbow Nation for the German ZYX label. Somerville enjoyed modest success in the Communards and has recorded periodically as a solo creative person since the late '80s.

Absolute Beginner

   
Artist: Absolute Beginner

   Genre(s): 
Rap: Hip-Hop
   

---

Discography:


   
 Bambule

   Year: 1998   
Tracks: 10

---

 





Rapper Warren G arrested on drug-related

Biz watches AFTRA-studio cliffhanger

Questions could be answered as last day of talks closes

Related Content Strike Zone: SAG/AMPTP

It was as tense and dramatic as any primetime drama's season finale: The industry was left in a holding pattern Tuesday, waiting for word about whether AFTRA had inked a deal on its primetime TV contract with the Alliance of Motion Picture & Television Producers.


The contract expires June 30, and Tuesday marked the last day of talks for AFTRA and the producers, with SAG waiting in the wings to restart its negotiations today.


No deal has been announced as of late Tuesday afternoon, but questions abound: Will there be yet another changing of the guard, with AFTRA not reaching a deal and SAG swooping in today to pick up where it left off on its formal talks? Or will AFTRA ask SAG to postpone its talks, just as SAG had done with its sister union during its 18 days of negotiations, which ended May 6? And if so, will SAG graciously say yes or refuse to give up its date with the AMPTP?


AFTRA and the AMPTP began formal negotiations May 7. Under a news blackout, little information about the talks has come out during the past 16 days other than two updates sent by AFTRA president Roberta Reardon to members and a "basic facts" message posted on the AMPTP's Web site.


In both, Reardon said that while progress had been made, the talks had not gone as smoothly as many watchers had expected, citing similar stumbling blocks SAG had revealed following its negotiating sessions with the producers.


The biggest roadblock for both unions is the re-use of actors' clips by the studios without individual consent. The AMPTP has proposed that an online clip library be established to combat the increasing Internet piracy of such excerpts while at the same time generating revenue. But administratively, the requirement to get consent from each actor to use those clips would be overwhelming.


"Under the rules of the existing SAG and AFTRA contracts -- rules which originated 50 years ago -- clips from the library, even those lasting only a few seconds, can only be used if the producer 'bargains' separately with every performer in the clip and reaches an agreement to pay each performer at least the day pay minimum of $759," the AMPTP said in a statement posted May 20 on its Web site. "This could require the producer to bargain hundreds or thousands of times with an individual performer over clips from a single series or feature. Hundreds of thousands of separate negotiations would be required to clear a library."


Reardon told members in a message this Sunday that the union's negotiating committee is standing firm in protecting members rights while "trying to think out of the box in order to reach pragmatic resolutions."


Reardon later added, "AFTRA is focused on working with employers to find a creative solution that will protect our members' images while at the same time encouraging the growth of the new market."


SAG also has indicated its willingness to work with the AMPTP, saying it's ready to return to the bargaining table, but it has issued stronger statements about giving up consent.


"They (AMPTP members) are now seeking to reach back into their vaults and release nonpromotional clips and sell them for use in various new-media platforms," SAG said in a statement to members last week. "As proposed, they want to use clips form all motion pictures and television shows produced to date and into through the future without your consent.


"While the companies have proposed nominal, nonnegotiable payments for the use, your right to consent and negotiate would be gone if we accept this proposal."


With the clip issue surfacing, the uncertainty of a deal has left most in the industry worried that another strike is imminent. Already, many studios are operating under de facto conditions by not scheduling any productions after June 30.


In the meantime, SAG has inked deals for guaranteed completion contracts with such indie producers as Yari Film Group and the Film Department. Under the agreements, SAG promises not to strike their productions in the event of an actor walkout.

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• Solange Knowles AKA SoL-AngeL Hits the Road for the ‘Art of Love’ Tour With Raheem DeVaughn and Chrisette Michele
• Enigmania

BET Networks Provides Comprehensive Coverage of Historic 2008 Presidential Campaign On-Air and Online

BET News Special "OBAMA'S JOURNEY TO THE WHITE HOUSE: TOP TEN MOMENTS" To
Be Re-Broadcast on Wednesday, June 4 at 7:30 p.m.*
BET.com's DECISION '08 Site Offers Informative Analysis and Updates from
the Campaigns, Including Blogs, Polls, Exclusive Videos and More

NEW YORK, June 4 -- In support of this year's historic
presidential race, BET will be re-airing the BET News special OBAMA'S
JOURNEY TO THE WHITE HOUSE: TOP TEN MOMENTS on Wednesday, June 4 at 7:30
p.m.* BET News will also be covering reactions to Obama's nomination with
news briefs throughout the day, culminating with the news special.

(Logo: http://www.newscom.com/cgi-bin/prnh/20070716/BETNETWORKSLOGO )

OBAMA'S JOURNEY TO THE WHITE HOUSE: TOP TEN MOMENTS originally aired on
BET on Tuesday, June 3, following BET's LIVE broadcast of Barack Obama's
groundbreaking speech regarding his win of the Democratic nomination.

OBAMA'S JOURNEY TO THE WHITE HOUSE: TOP TEN MOMENTS explores Obama's
path to becoming the Democratic front-runner in the race for President of
the United States. The special recalls the most memorable moments of this
historic campaign and features commentary from a number of entertainers and
opinion leaders, as well as video and interviews from the campaign trail
and beyond.

In addition to this informative news special, BET Networks is providing
its audiences with extensive coverage of this landmark development in the
2008 presidential election, both on-air and online:



-- YOU(th) VOTE! -- BET Networks' multiplatform initiative for Black
youth to discuss, debate and actively participate in this momentous
race to the White House broke the news of Obama's likely nomination
at 6:05 p.m. ET on Tuesday, June 3 with a post "Yes We Did," followed
by another post stressing the influence of young people's involvement
in Obama's win in "Dear Young American, YOUR VOICE HAS BEEN HEARD."

-- Another post will be set up today outlining the next steps for the
election and looking at which candidate will be more viable in the
eyes of young America.
-- On-air, there will be a YOU(th) VOTE!-branded blast noting Obama's
monumental nomination, giving the youth an opportunity to sound-off
on their thoughts on YOU(th) VOTE!
-- YOU(th) VOTE! Blog - Four college students blog daily, giving their
unique points of view on the presidential campaign and how the
national issues being debated are impacting pop culture, their lives
and life, more broadly, on their college campuses and in their
communities.

-- Pamela on Politics -- The blog by Pamela Gentry, Senior Political
Producer, BET News, will provide daily, up-to-the-minute, close-up
coverage of the presidential campaign.

-- Weekly Polls -- Weekly polls will survey our users on the hot-button
issues of the day.

-- Barack Obama Timeline -- An interactive timeline will detail defining
moments in Obama's life -- from his youth in Hawaii through his
collegiate years to his work as an activist and organizer and his life
as husband, father, elected official and presidential candidate.

-- McCain vs. Obama -- Users will be given an opportunity to rate the
political positions of the Obama and McCain campaign on key issues such
as affirmative action, health care, foreign policy, trade, etc.

-- The Running Mate Photo Gallery -- Who will be Vice President? Potential
Republican and Democratic Party vice presidential candidates will be
featured with short blurbs about their service and a poll that will
allows users to rate each one.

-- Video -- Missed it on TV? BET News video from the campaign trail and
other related political coverage will be available for the BET audience
to watch online. BET News will also offer exclusive political coverage
online.

All of BET Networks' presidential election coverage will be promoted on
BET's DECISION '08 site: http://www.bet.com/news/decision08.

*All times ET/PT

About BET Networks

BET Networks, a division of Viacom Inc. (NYSE: VIA, VIA.B), is the
nation's leading provider of quality entertainment, music, news and public
affairs television programming for the African-American audience. The
primary BET channel reaches more than 87 million households according to
Nielsen Media Research, and can be seen in the U.S., Canada and the
Caribbean. BET is the dominant African-American consumer brand with a
diverse group of business extensions: BET.com, a leading internet
destination for Black entertainment, music, culture, and news; BET Digital
Networks -- BET J, BET Gospel and BET Hip Hop, attractive alternatives for
cutting-edge entertainment tastes; BET Event Productions, a full-scale
event management and production company; BET Home Entertainment, a
collection of BET-branded offerings for the home environment including DVDs
and video-on-demand; BET Mobile, which provides ringtones, games and video
content for wireless devices; and BET International, an extension of BET
network programming for global distribution.




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Lily Allen - Allen Slams Unprofessional Paparazzi

LILY ALLEN has hit out at the photographers who took topless pictures of her while she was on holiday in France - insisting there is "nothing professional about them".

The Smile singer was snapped relaxing in only a pair of blue bikini bottoms at a French resort during the Cannes International Film Festival last week (beg19May08) - and her semi-naked form quickly made the headlines.

The star claims she is not ashamed of sunbathing topless, but insists there is nothing noble about being a prying paparazzo.

She writes on her MySpace internet page, "Occasionally I drink wine with lunch and yes I swim topless, this in my book is not embarrassing behaviour.

"I'm 23 years old, it's not my fault if photographers follow me everywhere and need a story to print with their pointless pictures. I wish digital cameras hadn't been invented, if these photographers had to pay for film, it wouldn't be worth their time. There is nothing professional about them, most of them look like they wouldn't be out of place at a BNP (British National Party) meeting."

And Allen goes on to deny stories that she was ejected from Formula One boss Flavio Briatore's yacht for drunken behaviour.

She adds, "I don't really like to respond to things I read about my self in the press but, for the record, I was not thrown off anybody's yacht in Cannes."

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Clock DVA

   
Artist: Clock DVA

   Genre(s): 
Industrial
   Other
   Electronic
   

---

Discography:


   
 Sign

   Year: 1993   
Tracks: 9


   
 Bitstream

   Year: 1992   
Tracks: 7


   
 Final program [EP]

   Year: 1991   
Tracks: 3


   
 Hacker [Hacked] [CD5]

   Year: 1989   
Tracks: 3


   
 Thirst

   Year: 1981   
Tracks: 11


   
 Voice Recognition Test

   Year:    
Tracks: 3


   
 The Act

   Year:    
Tracks: 4

---

A product of the same mid-'70s Sheffield industrial music community of interests which likewise gave rise up to Throbbing Gristle and Cabaret Voltaire, Clock DVA emerged in 1980 from the ashes of area bands including the Studs, Block Opposite, Veer and They Must Be Russians as well as the Future, an early incarnation of the Human League. After a serial of shifting lineups, a roster comprised of vocaliser Adi Newton, bassist Steven Taylor, guitarist Paul Widger, saxophonist Charlie Collins and drummer Roger Quail recorded Clock DVA's debut White Souls in Black Suits, a cassette-only, improvisational release fusing metallic noise with funk and soul designs which was issued on Throbbing Gristle's Industrial label.


In 1981, the grouping issued Hungriness, which abandoned R&B accoutrements in favor of jittery, abrasive electronic racket. Following its release, all of Clock DVA omit Newton defected to form Box; after collecting a unexampled lineup of saxophonist Paul Browse, future Siouxsie and the Banshees guitarist John Carruthers, bassist Dean Dennis and drummer Nick Sanderson, Newton wrangled a major-label deal with Polydor, and Clock DVA soon resurfaced with 1983's Vantage, an intense montage of dance beats, penetrative feedback and jarring tape measure manipulations. However, Carruthers and Sanderson both exited following the LP's release; after a brief attempt to forge on as a trio, Clock DVA disbanded in late 1983.


N later turned his focussing to the Anti Group, an industrial idle words and visual arts jut out created in tandem with engineer Robert Baker; after a series of singles, he reformed Clock DVA in 1988 with Browse and Dennis, cathartic the sample-fueled 1988 EPs The Hacker and The Act, as well as 1990's uncut Inhumed Dreams, on the Wax/Trax label. By 1991's Transitional Voices, Newton's Anti Group collaborator Baker had replaced Browse; Dennis departed shortly after, leaving the left duet to record a enormously prolific amount of material including 1992's Man-Amplified, 1993's Signaling, Black Words on White Paper and Virtual Reality Handbook, 1994's 150 Erotic Calibrations and 1995's Anterior.

Ken Nordine

   
Artist: Ken Nordine

   Genre(s): 
Jazz
   Vocal
   

---

Discography:


   
 A Transparent Mask

   Year: 2001   
Tracks: 20


   
 Colors

   Year: 2000   
Tracks: 34


   
 The Best of Word Jazz, Vol. 1

   Year: 1990   
Tracks: 18

---

Most Americans ar belike familiar with Cognizance Nordine, habitue if they don't fuck it. His rich people, mysterious baritone graces numerous tV and wireless ads. His to the highest degree creative work, however, is reserved for his "word jazz," which marries liquid, free connexion ruminations with gaudy instrumental funding. Active in radio since the fifties, he's recorded numerous albums and syndicated broadcasts, and has yet collaborated with the Grateful Dead.


Nordine got his start as a radiocommunication and telecasting personality in Chicago, were he would sometimes do his raps over laze words records on his poetry show. His first class honours degree degree News Jazz record album, from 1957, utilized the Chico Hamilton stria (workings under the false name of the Fred Katz chemical substance grouping). This lED to a series of Parole Wind recordings, which -- like the beat poetry from the sami era -- looked beyond the conformance of the fifties to more imaginative and colourful worlds, ones that had room for partiality and unreason, and non just now mundane reality. He's recorded sporadically of whole meter since, although he does studio recordings as a sideline to his influence in wireless and commercials. Nordine's soundscapes ar best experient not on his comparatively few commercial-grade recordings, only on his syndicated radiocommunication countersink shows, 375 of which are uncommitted on cassette from Snail Records, Box 285-8C2, Florence, WI 54121.

XRS

   
Artist: XRS

   Genre(s): 
Drum & Bass
   

---

Discography:


   
 System Halt X Type

   Year: 2007   
Tracks: 1


   
 Crowds In The Clouds REMIX - W

   Year: 2005   
Tracks: 2


   
 Wildstyle (WILDSTYLE002)

   Year: 2004   
Tracks: 2

---

 





Von Bondies return with new LP, tour

Arctic Monkeys dominate NME shortlist

Arctic Monkeys dominate NME shortlist

Arctic Monkeys jumper lead this year's NME Music Awards shortlist with nominations in septenary categories.
The grouping has been nominated in the Best British Band, Best Live Lot, Best Record album, Best Raceway, Best Video and Best Video Album Graphics categories.
Lead isaac Bashevis Singer Alex Food turner has likewise been shortlisted for the C. H. Best Dressed award.
NME music magazine said the nominations, which ar selected by public vote, made the radical the most voted-for band of the 10.
Arctic Monkeys guitarist Jamie Cook said: "It's sound the readers hold ballot for us."
"Live would be goodness - it's trade good to have been picked up in that because we put a lot of effort into our live work shoemaker's last class, I mentation we got a set better."
Klaxons take been nominated in tetrad NME categories, contesting Best British Banding, Best Album, Best Video and Best Dance Storey Filler.
Contesting the Topper Brits Band category aboard the Arctic Zone Monkeys and Klaxons are Babyshambles, The Cribs and Muse.
Troubled singer Amy Winehouse has likewise been nominated for foursome awards - Villain of the Year, Worst Dressed, Best Music DVD and Charles Herbert Best Solo Artist.
Winehouse faces competition from Kate Nash, Jamie T, Jack Penate and St. Patrick Wolf in the Best Solo Creative person category.
Nominated in the Best International Band category are Colonnade Fire, Foo Fighters, the Killers, Kings of Leon and My Chemical substance Love affair.
The nominations for Best Album ar 'Favourite Worst Nightmare' by Arctic Monkeys, 'Shotters Nation' by Babyshambles, 'We'll Live and Die in These Towns' by The Enemy, 'Myths of the Near Future' by Klaxons and 'In Rainbows' by Radiohead.
The Best Running shortlist includes 'Fluorescent Adolescent' by Gumshoe Monkeys, 'Flux' by Axis Party, 'Men's Needs' by The Cribs, 'Lord Don't Slow up Me Down' by Oasis and 'Let's Dance to Joyfulness Division' by The Wombats.




Kelly Brook - Brook And Zane Reunited

Arrested Development movie planned?

Arrested Development movie planned?

Popular US situation comedy 'Arrested Development' is to be made into a picture show, according to the shows star topology Jason Bateman.
Bateman told US TV picture E! Tidings that plans ar underway for a picture show version of the cancelled show.
Rumours of a big-screen adaptation of the cult show began to circulate last year after the actor was reported to experience met with series divine Mitch Hurwitz.
Now Bateman, world Health Organization presently stars in 'Juno', has confirmed the redact has received calls from executives asking if they would be interested in reviving their roles in one case the ongoing Hollywood writers coin is over.
He told E! News: "I bathroom confirm that a round of golf of sniffing has started. Any babble is targeting a post-strike situation, of line.
"I suppose, as always, that it's a doubt of whether the multitude with the money are volition to pass on our leader, Mitch Hurwitz, what he deserves for his participation. And I tin talk for the draw when I aver our fingers ar crossed."

Oszilla

   
Artist: Oszilla

   Genre(s): 
Trance: Psychedelic
   

---

Discography:


   
 Return to Neverland

   Year: 2003   
Tracks: 10

---